Chimeric orthopoxvirus
WebSep 9, 2024 · One such OV is CF33, a chimeric poxvirus created by chimerization of nine species of orthopoxvirus, including multiple strains of vaccinia virus selected for enhanced anti-tumor activity.23, 24, 25 CF33 has a mutation in the J2R (thymidine kinase [TK]) gene, and hence it depends on the cellular pool of thymidine triphosphate. WebCF33-hNIS-antiPDL1, a chimeric orthopoxvirus expressing the human sodium iodide symporter (hNIS) and anti-human programmed death-ligand 1 antibody, has demonstrated robust preclinical activity ...
Chimeric orthopoxvirus
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Weborthopoxvirus vectors, genes and products thereof专利检索，orthopoxvirus vectors, genes and products thereof属于···痘苗病毒或天花病毒专利检索，找专利汇即可免费查询专利，···痘苗病毒或天花病毒专利汇是一家知识产权数据服务商，提供专利分析，专利查询，专利检索等数据服务功能。 WebJun 29, 2024 · One hundred chimeric orthopoxvirus plaques were picked from CV-1 cells infected with the chimeric orthopoxvirus pool. These 100 plaques were further plaque purified two more times in CV-1 cells to yield 100 clonally purified individual chimeric virus isolates, which, together with the parental viruses, were subjected to high-throughput ...
WebJun 6, 2024 · CF33-hNIS Infects, Replicates in, and Kills Colon Cancer Cells. Chimerization and high-throughput analysis yielded a successful chimeric orthopoxvirus candidate that resulted in superior cell killing and viral replication when compared with parental strains, as previously reported.14, 15, 16 Insertion of hNIS at the tk locus (Figure 1 A) resulted in … WebFor these studies, we used an oncolytic chimeric orthopoxvirus, designed to infect a large spectrum of tumors (13) (14)(15)(16)(17), carrying CD19t under the control of the vaccinia synthetic ...
WebOct 9, 2024 · The conditionally replication-competent chimeric orthopoxvirus (CF17) successfully exhibited the ability to suppress tumor growth and increase survival in preclinical peritoneal ovarian metastases … Orthopoxvirus is a genus of viruses in the family Poxviridae and subfamily Chordopoxvirinae. Vertebrates, including mammals and humans, and arthropods serve as natural hosts. There are 12 species in this genus. Diseases associated with this genus include smallpox, cowpox, horsepox, camelpox, and monkeypox. The most widely known member of the genus is Variola virus, which causes smallpox. It was eradicated globally by 1977, through the use of Vaccinia virus as a vac…
WebCF33-hNIS-antiPDL1 is a genetically engineered chimeric orthopoxvirus, CF33, armed with the human Sodium Iodide Symporter (hNIS) and anti-PD-L1 antibody (anti-PD-L1). …
WebJun 17, 2024 · A novel oncolytic chimeric orthopoxvirus encoding luciferase enables real-time view of colorectal cancer cell infection. Mol Ther Oncolytics. 2024;9:13–21. PubMed PubMed Central Google Scholar chiropractic massage roller tableWebApr 26, 2024 · Detailed Description: CF33-hNIS, a novel chimeric orthopoxvirus, will be administered as a monotherapy or in combination with pembrolizumab to assess the … graphics brief 2022WebStudy design: CF33-hNIS-antiPDL1 is a genetically engineered chimeric orthopoxvirus, CF33, armed with the human Sodium Iodide Symporter (hNIS) and anti-PD-L1 antibody … graphics by evaWebSep 25, 2024 · One such OV is CF33, a chimeric poxvirus created by chimerization of nine species of orthopoxvirus, including multiple strains of vaccinia virus selected for enhanced anti-tumor activity. 23, 24, 25 CF33 has a mutation in the J2R (thymidine kinase [TK]) gene, and hence it depends on the cellular pool of thymidine triphosphate. chiropractic massage singaporeWebJun 2, 2024 · CF33-hNIS-anti-PD-L1 (CHECKvacc) is a novel chimeric orthopoxvirus with robust anti-cancer activity in TNBC xenografts. Cells infected with CHECKvacc were shown to express functional human sodium-iodide symporter (hNIS) and anti-PD-L1 proteins. hNIS gene transfer allows tracking of virus by 99mTc single-photon emission computed … chiropractic massage sarasota floridaWebOrthopoxvirus is a genus of viruses in the family Poxviridae and subfamily Chordopoxvirinae.Vertebrates, including mammals and humans, and arthropods serve as natural hosts. There are 12 species in this genus. … graphics bus interfaceWebSep 25, 2024 · Anthony K. Park et.al utilized an oncolytic chimeric orthopoxvirus carrying a CD19t-encoding gene to infect solid tumor cells including those of pancreatic cancer, prostate cancer, and breast cancer. They demonstrated that OVs can effectively deliver the CD19-CAR target to solid tumors and upregulate the expression of CD19t on the surface … chiropractic massages near me